Followers | 5 |
Posts | 528 |
Boards Moderated | 0 |
Alias Born | 07/16/2013 |
Tuesday, January 01, 2019 12:29:00 PM
https://patents.justia.com/patent/8956621
Here is an excerpt:
Safety and Efficacy of LM-LLO-E7 for the Treatment of Cervical Intraepithelial Neoplasia
Advaxis has treated 45 patients with grade 2 or 3 Cervical Intraepithelial Neoplasia (cervical dysplasia) thus far in a trial designed to treat 120 patents. Three treatment groups of 40 patients each are comprised of 10 patients who get placebo on a randomized basis and 30 patients who get active drug at 5.107, 3.3×108 or 1×109 cfu. A safety run in of 3 patients is conducted for each dosage group and these patients receive the active drug. The remaining 37 patients are randomized to either placebo or active drug at a ratio of 3 active patients for each placebo patient. The trial involves the administration of Advaxis agent ADXS11-001 directed against HPV 16-E7 3 times at 28 day intervals followed by a surgical LEEP procedure 6 months after the initial dose. Pretreatment biopsy samples are compared with post treatment LEEP surgery specimens for an assessment of histologic response.
The objective of this study was to see whether a vaccine regimen can replace surgery. Aside from the pain, bleeding, and other aspects of surgery, the removal of a portion of the cervix often leads to an inability to come to a full term pregnancy (“incompetent cervix”). A pharmaceutical treatment would thus be preferential to surgery. Especially one that induces immunologic memory against the etiologic agent that causes cervix cancer, HPV, in a manner that protects against recurrence.
At the present time the random code has not been broken, however of the 18 treated patients 3-4 patients have receive placebo and 14-15 patients have received active drug. The average spontaneous remission rate in this population is approximately 25%, and 4-5 patients spontaneously remit assuming the experimental agent was ineffective, but in the 18 patients treated to date, irrespective of treatment, 14 have remitted. Thus, a therapeutic effect of the agent on the precancerous condition of CIN is being observed.
I am not a trained financial professional, and all posts are my bar stool amateur opinion.
Recent ADXS News
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 03/06/2024 12:13:01 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 03/05/2024 09:30:45 PM
- Form DEFM14C - Definitive information statement relating to merger or acquisition • Edgar (US Regulatory) • 03/05/2024 01:16:24 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/23/2024 09:30:46 PM
- Form PREM14C - Preliminary information statements relating to merger or acquisition • Edgar (US Regulatory) • 02/20/2024 10:22:48 PM
- Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 02/14/2024 09:26:22 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/12/2024 07:16:21 PM
- Form SC 13D/A - General statement of acquisition of beneficial ownership: [Amend] • Edgar (US Regulatory) • 02/12/2024 04:58:05 PM
- Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 02/12/2024 01:27:51 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/09/2024 10:15:23 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/06/2024 01:51:21 PM
- Form 8-K/A - Current report: [Amend] • Edgar (US Regulatory) • 01/03/2024 09:18:58 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 11/21/2023 02:04:41 PM
- Form SC 13D/A - General statement of acquisition of beneficial ownership: [Amend] • Edgar (US Regulatory) • 11/21/2023 02:00:50 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/20/2023 02:00:30 PM
- Form NT 10-Q - Notification of inability to timely file Form 10-Q or 10-QSB • Edgar (US Regulatory) • 11/15/2023 09:04:59 PM
- Form 3 - Initial statement of beneficial ownership of securities • Edgar (US Regulatory) • 11/08/2023 09:01:18 PM
- Form 3/A - Initial statement of beneficial ownership of securities: [Amend] • Edgar (US Regulatory) • 11/03/2023 03:46:10 PM
- Form 3/A - Initial statement of beneficial ownership of securities: [Amend] • Edgar (US Regulatory) • 11/03/2023 03:45:26 PM
- Form 3/A - Initial statement of beneficial ownership of securities: [Amend] • Edgar (US Regulatory) • 11/03/2023 03:43:16 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 10/31/2023 11:08:02 AM
- Form SC 13D/A - General statement of acquisition of beneficial ownership: [Amend] • Edgar (US Regulatory) • 10/31/2023 11:05:10 AM
- Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 10/23/2023 10:45:21 AM
NanoViricides Reports that the Phase I NV-387 Clinical Trial is Completed Successfully and Data Lock is Expected Soon • NNVC • May 2, 2024 10:07 AM
ILUS Files Form 10-K and Provides Shareholder Update • ILUS • May 2, 2024 8:52 AM
Avant Technologies Names New CEO Following Acquisition of Healthcare Technology and Data Integration Firm • AVAI • May 2, 2024 8:00 AM
Bantec Engaged in a Letter of Intent to Acquire a Small New Jersey Based Manufacturing Company • BANT • May 1, 2024 10:00 AM
Cannabix Technologies to Deliver Breath Logix Alcohol Screening Device to Australia • BLO • Apr 30, 2024 8:53 AM
Hydromer, Inc. Reports Preliminary Unaudited Financial Results for First Quarter 2024 • HYDI • Apr 29, 2024 9:10 AM